As a result of the crash, two tractor trailer trucks were totally consumed by fire. One person was killed.
Weather conditions at the time of the crash were dense fog and black ice on the roadway.
The crash happened near the Vedauwoo Interchange around 2:30 a.m. Four victims were transported to nearby hospitals, but one of those victims has been transferred to a hospital in Colorado.
Motorists are asked to check the web site at www.wyoroad.info or dial 1-888-WYOROAD for road conditions and closure information.